Recombinant Human SEMA3C Protein, His-tagged

• Cat.No.: SEMA3C-353H
• Product Overview: Recombinant Human SEMA3C(Gly21-Ser738) fused with His tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• ProteinLength: Gly21-Ser738
• Description: This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.4.
• Molecular Mass: 82.4 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [ Homo sapiens ]
• Official Symbol: SEMA3C
• Synonyms: SemE; SEMAE
• Gene ID: 10512
• mRNA Refseq: NM_006379.3
• Protein Refseq: NP_006370.1
• MIM: 602645
• UniProt ID: Q99985