Recombinant Human SELENOW Protein (Met1-Gly86), His tagged

• Cat.No.: SELENOW-5470H
• Product Overview: Recombinant human SELENOW (Met1-Gly86) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: Met1-Gly86
• Description: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 11.19 kDa
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SELENOW selenoprotein W [ Homo sapiens (human) ]
• Official Symbol: SELENOW
• Synonyms: SELENOW; selenoprotein W; selW; SEPW1; selenoprotein W; selenoprotein W, 1
• Gene ID: 6415
• mRNA Refseq: NM_003009
• Protein Refseq: NP_003000
• MIM: 603235
• UniProt ID: P63302