Recombinant Human SELE Protein, His-tagged

• Cat.No.: SELE-128H
• Product Overview: Recombinant Human SELE Protein with His tag was expressed in E. coli.

Specification

• Description: Selectins, also designated CD62 antigens, comprise a family of carbohydratebinding proteins involved in mediating cellular interactions with leukocytes. L-Selectin (also designated LECAM-1 or CD62L) is expressed on the majority of B and naive T cells and on most monocytes, neutrophils and eosinophils. L-Selectin interacts with specific carbohydrates expressed by activated endothelial cells. P-Selectin (also designated GMP-140 or CD62P), expressed on activated platelets and endothelial cells, and E-Selectin (also designated ELMA-1 or CD62E), expressed on endothelial cells, exhibit overlapping ligand specificities. E-Selectin is expressed by cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~62 kDa
• AA Sequence: MWSYNTSTEAMTYDEASAYCQQRYT HLVAIQNKEEIEYLNSILSYSPSYY WIGIRKVNNVWVWVGTQKPLTEEAK NWAPGEPNNRQKDEDCVEIYIKREK DVGMWNDERCSKKKLALCYTAACTN TSCSGHGECVETINNYTCKCDPGFS GLKCEQIVNCTALESPEHGSLVCSH PLGNFSYNSSCSISCDRGYLPSSME TMQCMSSGEWSAPIPACNVVECDAV TNPANGFVECFQNPGSFPWNTTCTF DCEEGFELMGAQSLQCTSSGNWDNE KPTCKAVTCRAVRQPQNGSVRCSHS PAGEFTFKSSCNFTCEEGFMLQGPA QVECTTQGQWTQQIPVCEAFQCTAL SNPERGYMNCLPSASGSFRYGSSCE FSCEQGFVLKGSKRLQCGPTGEWDN EKPTCEAVRCDAVHQPPKGLVRCAH SPIGEFTYKSSCAFSCEEGFELHGS TQLECTSQGQWTEEVPSCQVVKCSS LAVPGKINMSCSGEPVFGTVCKFAC PEGWTLNGSAARTCGATGHWSGLLP TCEAPTESNIP
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Storage Buffer: PBS, 4M Urea, pH7.4
• Protein length: 22-556 a.a.

Gene Information

• Gene Name: SELE selectin E [ Homo sapiens (human) ]
• Official Symbol: SELE
• Synonyms: SELE; selectin E; ELAM, ELAM1, endothelial adhesion molecule 1; E-selectin; CD62E; ESEL; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; ELAM; ELAM1; LECAM2
• Gene ID: 6401
• mRNA Refseq: NM_000450
• Protein Refseq: NP_000441
• MIM: 131210
• UniProt ID: P16581

Reviews

11/26/2020

With its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.

09/08/2019

In addition to its outstanding quality, the SELE Protein exhibits exceptional stability during storage and usage.

06/16/2019

Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.

Q&As

Is there a diagnostic test to measure SELE levels in patients?

Some diagnostic tests can measure SELE levels in the blood, providing insights into the inflammatory status of an individual.

Can SELE protein be involved in cancer progression?

Emerging research suggests a potential role of SELE in cancer metastasis, making it a target for investigation in cancer therapy.

Are there any genetic factors influencing SELE expression?

Genetic variations can influence SELE expression, contributing to individual differences in inflammatory responses.

How does SELE protein interact with circulating immune cells?

SELE binds to specific receptors on immune cells, facilitating their adhesion to endothelial cells and promoting their migration to inflammatory sites.

Can targeting SELE protein be a potential strategy for anti-inflammatory therapies?

Yes, drugs designed to modulate SELE activity are being explored as potential anti-inflammatory agents.