Recombinant Human RUNX3, His-tagged

• Cat.No.: RUNX3-31339TH
• Product Overview: Recombinant fragment, corresponding to amino acids 53-186 of Human RUNX3 with N terminal His tag; 155 amino acids with tag, MWt 17.1kDa.

Specification

• Description: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5-PYGPYGGT-3 found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 134 amino acids
• Conjugation: HIS
• Molecular Weight: 17.100kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK
• Sequence Similarities: Contains 1 Runt domain.

Gene Information

• Gene Name: RUNX3 runt-related transcription factor 3 [ Homo sapiens ]
• Official Symbol: RUNX3
• Synonyms: RUNX3; runt-related transcription factor 3; CBFA3; AML2; PEBP2A3
• Gene ID: 864
• mRNA Refseq: NM_001031680
• Protein Refseq: NP_001026850
• MIM: 600210
• Uniprot ID: Q13761
• Chromosome Location: 1p36
• Pathway: Endochondral Ossification, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem
• Function: ATP binding; DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; protein binding; sequence-specific DNA binding RNA polymerase II transcription factor activity