Recombinant Human RRM2, T7 -tagged

• Cat.No.: RRM2-30111TH
• Product Overview: Recombinant full length protein (Human). T7 tag at N-terminus.

Specification

• Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
• Conjugation: T7
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton-X-100, 10mM Tris, 10mM DTT, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the ribonucleoside diphosphate reductase small chain family.
• Full Length: Full L.

Gene Information

• Gene Name: RRM2 ribonucleotide reductase M2 [ Homo sapiens ]
• Official Symbol: RRM2
• Synonyms: RRM2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2
• Gene ID: 6241
• mRNA Refseq: NM_001034
• Protein Refseq: NP_001025
• MIM: 180390
• Uniprot ID: P31350
• Chromosome Location: 2p25-p24
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem
• Function: oxidoreductase activity; ribonucleoside-diphosphate reductase activity; ribonucleoside-diphosphate reductase activity; transition metal ion binding