Recombinant Human RPS6KA3, GST-tagged, Active

• Cat.No.: RPS6KA3-425H
• Product Overview: Recombinant full-length human RPS6KA3 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=112kDa.

Specification

• Cat. No.: RPS6KA3-425H
• Description: RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression. Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• nullValue_other: Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Signalling by NGF

Gene Information

• Gene Name: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [ Homo sapiens ]
• Synonyms: RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3; mental retardation, X-linked 19; insulin-stimulated protein kinase 1; EC 2.7.11.1
• Gene ID: 6197
• mRNA Refseq: NM_004586
• Protein Refseq: NP_004577
• MIM: 300075
• UniProt ID: P51812
• Chromosome Location: Xp22.2-p22.1
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; transferase activity; protein serine/threonine kinase activity