Recombinant Human RNF7 Protein, MYC/DDK-tagged

• Cat.No.: RNF7-670H
• Product Overview: Recombinant Human RNF7, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 12.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNF7 ring finger protein 7 [ Homo sapiens ]
• Official Symbol: RNF7
• Synonyms: RNF7; ring finger protein 7; RING-box protein 2; CKBBP1; ROC2; SAG; sensitive to apoptosis; zinc RING finger protein SAG; regulator of cullins 2; rbx2; CKII beta-binding protein 1; sensitive to apoptosis gene protein; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
• Gene ID: 9616
• mRNA Refseq: NM_014245
• Protein Refseq: NP_055060
• MIM: 603863
• UniProt ID: Q9UBF6