Recombinant Human RLN2, His-tagged

• Cat.No.: RLN2-7081H
• Product Overview: Recombinant human RLN2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: Prorelaxin H2, also known as RLN2, belongs to the insulin gene superfamily. This family is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. RLN2 is a peptide hormone associated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. RLN1 and RLN2 share high sequence homology.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea,10% glycerol
• Molecular Mass: 20.7 kDa (184aa)
• Protein length: 25-185aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSDSWMEEV IKLCGRELVR AQIAICGMST WSKRSLSQED APQTPRPVAE IVPSFINKDT ETINMMSEFVANLPQELKLT LSEMQPALPQ LQQHVPVLKD SSLLFEEFKK LIRNRQSEAA DSSPSELKYL GLDTHSRKKR QLYSALANKC CHVGCTKRSL ARFC
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: RLN2 relaxin 2 [ Homo sapiens ]
• Official Symbol: RLN2
• Synonyms: RLN2; relaxin 2; relaxin 2 (H2); prorelaxin H2; bA12D24.1.1; bA12D24.1.2; H2; relaxin H2; relaxin; ovarian; of pregnancy; RLXH2; relaxin, ovarian, of pregnancy
• Gene ID: 6019
• mRNA Refseq: NM_005059
• Protein Refseq: NP_005050
• MIM: 179740
• UniProt ID: P04090
• Chromosome Location: 9pter-q12
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Relaxin receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: hormone activity