Recombinant Human RAB3B, T7-tagged

• Cat.No.: RAB3B-2976H
• Product Overview: Recombinant Human RAB3B (1-219 aa) is expressed in E.Coli with a T7 tag at N-terminus.

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Protein Length: 1-219 a.a.
• Description: In Parkinson"s disease (PD), dopaminergic (DA) neurons in the substantia nigra (SN, A9) are particularly vulnerable, compared to adjacent DA neurons within the ventral tegmental area (VTA, A10). Here, we show that in rat and human, one RAB3 isoform, RAB3B, has higher expression levels in A10 compared to A9 neurons. RAB3 is a monomeric GTPase protein that is highly enriched in synaptic vesicles and is involved in synaptic vesicle trafficking and synaptic transmission, disturbances of which have been implicated in several neurodegenerative diseases, including PD.
• MW: 24758 Da.
• Purity: 95%.
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3.
• Application: MS. SDS.

Gene Information

• Gene Name: RAB3B RAB3B, member RAS oncogene family [ Homo sapiens ]
• Synonyms: RAB3B; RAB3B, member RAS oncogene family;brain antigen RAB3B; ras-related protein Rab-3B; RAB3B, member RAS oncogene family
• Gene ID: 5865
• mRNA Refseq: NM_002867
• Protein Refseq: NP_002858
• MIM: 179510
• UniProt ID: P20337
• Chromosome Location: 1p32-p31
• Pathway: Tight junction
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding