Recombinant Human RAB23, Member RAS Oncogene Family, His-tagged

• Cat.No.: RAB23-1290H
• Product Overview: Recombinant human RAB23 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Species: Human
• Source: Human
• Tag: His
• ProteinLength: 1-234 a.a.
• Description: RAB23, also known as ras-related protein Rab23, is a member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. This protein is thought to to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. RAB23 is an essential negative regulator of the Sonic hedgehog signaling pathway. Mutations in the gene encoding RAB23 may result in Carpenter syndrome a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 1mM DTT, 0.1mM PMSF
• Molecular Weight: 28.5 kDa (254aa), confirmed by MALDI-TOF
• Purity: > 90% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSC
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Hedgehog Signaling Pathway; Hedgehog signaling events mediated by Gli proteins; Hedgehog signaling pathway

Gene Information

• Gene Name: RAB23 RAB23, member RAS oncogene family [ Homo sapiens ]
• Official Symbol: RAB23
• Synonyms: RAB23; RAB23, member RAS oncogene family; HSPC137; MGC8900; DKFZp781H0695; ras-related protein Rab-23; OTTHUMP00000016667; RAB family small GTP binding protein RAB 23; Ras-related protein Rab-23
• Gene ID: 51719
• mRNA Refseq: NM_016277
• Protein Refseq: NP_057361
• MIM: 606144
• UniProt ID: Q9ULC3
• Chromosome Location: 6p11
• Function: GTP binding; nucleotide binding