Recombinant Human PTEN Induced Putative Kinase 1

• Cat.No.: PINK1-1347H
• Product Overview: Recombinant human PINK protein was expressed in E. coli and purified by using conventional chromatography techniques. MW: 37.9 kDa.

Specification

• Description: PINK1 is a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this protein cause one form of autosomal recessive early-onset Parkinson disease.
• Source: E. coli
• Species: Human
• Tag: Non
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) 1M Urea, 5% Glycerol.
• Molecular Mass: 37.9 kDa (353aa)
• Protein length: 156-507aa
• AA Sequence: MYLIGQSIGK GCSAAVYEAT MPTLPQNLEV TKSTGLLPGR GPGTSAPGEG QERAPGAPAF PLAIKMMWNI SAGSSSEAIL NTMSQELVPA SRVALAGEYG AVTYRKSKRG PKQLAPHPNI IRVLRAFTSS VPLLPGALVD YPDVLPSRLH PEGLGHGRTL FLVMKNYPCT LRQYLCVNTP SPRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVL
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PINK1 PTEN induced putative kinase 1 [ Homo sapiens ]
• Official Symbol: PINK1
• Synonyms: PINK1; PTEN induced putative kinase 1; PARK6, Parkinson disease (autosomal recessive) 6; serine/threonine-protein kinase PINK1, mitochondrial; protein kinase BRPK; PTEN-induced putative kinase protein 1; BRPK; PARK6; FLJ27236
• Gene ID: 65018
• mRNA Refseq: NM_032409
• Protein Refseq: NP_115785
• MIM: 608309
• UniProt ID: Q9BXM7
• Chromosome Location: 1p36.12
• Pathway: Parkinsons disease, organism-specific biosystem
• Function: ATP binding; C3HC4-type RING finger domain binding; calcium-dependent protein kinase activity; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; ubiquitin protein ligase binding