Recombinant Human PTBP1 Protein (Met1-Ile531), His tagged
Cat.No. : | PTBP1-6054H |
Product Overview : | Recombinant human PTBP1 (Met1-Ile531) fused with His tag was expressed in E. coli. |
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Description : | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 55.72 kDa |
Protein length : | Met1-Ile531 |
Purity : | > 90 % as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name | PTBP1 polypyrimidine tract binding protein 1 [ Homo sapiens (human) ] |
Official Symbol | PTBP1 |
Synonyms | PTBP1; polypyrimidine tract binding protein 1; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), PTB; polypyrimidine tract-binding protein 1; heterogeneous nuclear ribonucleoprotein I; HNRNP I; HNRPI; pPTB; PTB 1; PTB2; PTB3; PTB4; hnRNP I; RNA-binding protein; 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein polypeptide I; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); PTB; PTB-1; PTB-T; HNRNPI; HNRNP-I; MGC8461; MGC10830; |
Gene ID | 5725 |
mRNA Refseq | NM_002819 |
Protein Refseq | NP_002810 |
MIM | 600693 |
UniProt ID | P26599 |
Not For Human Consumption!
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