Recombinant Human PTBP1 Protein (Met1-Ile531), His tagged

Cat.No. : PTBP1-6054H
Product Overview : Recombinant human PTBP1 (Met1-Ile531) fused with His tag was expressed in E. coli.
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Description : Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized powder/frozen liquid
Molecular Mass : 55.72 kDa
Protein length : Met1-Ile531
Purity : > 90 % as determined by SDS-PAGE
Notes : For research use only.
Storage : Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer : Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
Reconstitution : Reconstitute in sterile water for a stock solution.
Shipping : They are shipped out with dry ice/blue ice unless customers require otherwise.
Gene Name PTBP1 polypyrimidine tract binding protein 1 [ Homo sapiens (human) ]
Official Symbol PTBP1
Synonyms PTBP1; polypyrimidine tract binding protein 1; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), PTB; polypyrimidine tract-binding protein 1; heterogeneous nuclear ribonucleoprotein I; HNRNP I; HNRPI; pPTB; PTB 1; PTB2; PTB3; PTB4; hnRNP I; RNA-binding protein; 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein polypeptide I; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); PTB; PTB-1; PTB-T; HNRNPI; HNRNP-I; MGC8461; MGC10830;
Gene ID 5725
mRNA Refseq NM_002819
Protein Refseq NP_002810
MIM 600693
UniProt ID P26599

Not For Human Consumption!

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