Recombinant Human PSMD13, His-tagged

• Cat.No.: PSMD13-212H
• Product Overview: PSMD13, 1-376aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-376aa
• Description: PSMD13 belongs to the proteasome subunit S11 family and contains 1 PCI domain. This protein acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Recombinant human PSMD13 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 45.3kDa (399aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMKDVPGF LQQSQNSGPG QPAVWHRLEE LYTKKLWHQL TLQVLDFVQD PCFAQGDGLI KLYENFISEF EHRVNPLSLV EIILHVVRQM TDPNVALTFL EKTREKVKSS DEAVILCKTA IGALKLNIGD LQVTKETIED VEEMLNNLPG VTSVHSRFYD LSSKYYQTIG NHASYYKDAL RFLGCVDIKD LPVSEQQERA FTLGLAGLLG EGVFNFGELL MHPVLESLRN TDRQWLIDTL YAFNSGNVER FQTLKTAWGQ QPDLAANEAQ LLRKIQLLCL MEMTFTRPAN HRQLTFEEIA KSAKITVNEV ELLVMKALSV GLVKGSIDEV DKRVHMTWVQ PRVLDLQQIK GMKDRLEFWC TDVKSMEMLV EHQAHDILT
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [ Homo sapiens ]
• Official Symbol: PSMD13
• Synonyms: PSMD13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13; 26S proteasome non-ATPase regulatory subunit 13; p40.5; Rpn9; 26S proteasome subunit p40.5; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit p40.5; S11; HSPC027
• Gene ID: 5719
• mRNA Refseq: NM_002817
• Protein Refseq: NP_002808
• MIM: 603481
• UniProt ID: Q9UNM6
• Chromosome Location: 11p15.5
• Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem