Recombinant Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A, His-tagged

• Cat.No.: PPP1R1A-341H
• Product Overview: Recombinant Full Length human IPP-1, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (179 aa, 20 kDa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-171 a.a.
• Description: Protein phosphatase inhibitor-1(IPP-1) plays an important role in the regulation of glycogen metabolism through inhibition of type-1 protein serine/threonine phosphatase(PP1) activity, and it has been implicated in the regulation of cell growth. IPP-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. In the presence of calcium, PPI-1 is inactivated by calcineurin (or PP2B).
• Formulation: Liquid. In 50 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol.
• Molecular Weight: 20 kDa (179 aa).
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequence: MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PPP1R1A
• Synonyms: PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A; I-1; IPP-1; IPP1; inhibitor-1; protein phosphatase inhibitor-1; Protein phosphatase inhibitor 1.
• Gene ID: 5502
• mRNA Refseq: NM_006741.3
• Protein Refseq: NP_006732.3
• UniProt ID: Q13522
• Chromosome Location: 15q15.1-q15.2
• Pathway: Long-term potentiation.
• Function: protein binding; protein serine/threonine phosphatase inhibitor activity.