Recombinant Human Protein Arginine Methyltransferase 3, GST-tagged

• Cat.No.: PRMT3-1617H
• Product Overview: Recombinant full-length human PRMT3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: PRMT3-1617H
• Description: PRMT3 is a protein arginine methyltransferase that catalyze the formation of asymmetric N (G),N (G)-dimethylarginine (ADMA) residues in proteins. 40S ribosomal protein S2 is a physiological substrate of PRMT3 and PRMT3 regulates ribosome biosynthesis at a stage beyond pre-rRNA processing. DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene that can significantly inhibits PRMT3 methylation of cellular substrates. Modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth.
• Applications: Western Blot
• Molecular Weight: 97 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol, 0.1 mM EDTA.
• Purity: > 90 %
• Concentration: 0.1 ug/ul
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PRMT3 protein arginine methyltransferase 3 [ Homo sapiens ]
• Official Symbol: PRMT3
• Synonyms: PRMT3; protein arginine methyltransferase 3; HRMT1L3; HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae); Protein arginine N-methyltransferase 3; EC 2.1.1;Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
• Gene ID: 10196
• mRNA Refseq: NM_001145166
• Protein Refseq: NP_001138638
• MIM: 603190
• UniProt ID: O60678
• Chromosome Location: 11p15.1
• Function: metal ion binding; protein-arginine N-methyltransferase activity; transferase activity; zinc ion binding