Recombinant Human PRKCQ

• Cat.No.: PRKCQ-30178TH
• Product Overview: Recombinant full length Human PKC theta with an N terminal enzyme tag.Expressed by Baculovirus in Sf9 insect cells.

Specification

• Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
• Tissue specificity: Skeletal muscle, megakaryoblastic cells and platelets.
• Biological activity: Specific activity: 792 nmol/min/mg
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
• Tag: Non
• Full Length: Full L.

Gene Information

• Gene Name: PRKCQ protein kinase C, theta [ Homo sapiens ]
• Official Symbol: PRKCQ
• Synonyms: PRKCQ; protein kinase C, theta; protein kinase C theta type
• Gene ID: 5588
• mRNA Refseq: NM_001242413
• Protein Refseq: NP_001229342
• MIM: 600448
• Uniprot ID: Q04759
• Chromosome Location: 10p15
• Pathway: Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity