Recombinant Human PRKAB2 protein, His/MBP-tagged

• Cat.No.: PRKAB2-368H
• Product Overview: Recombinant Human PRKAB2(117-225 aa) fused with His/MBP tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His&MBP
• Protein Length: 117-225 aa
• Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
• Form: Liquid in PBS
• Purity: SDS-PAGE >90%
• Applications: WB Positive Control
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Homo sapiens ]
• Official Symbol: PRKAB2
• Synonyms: PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit; 5-AMP-activated protein kinase subunit beta-2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; 5-AMP-activated protein kinase, beta-2 subunit; MGC61468
• Gene ID: 5565
• mRNA Refseq: NM_005399
• Protein Refseq: NP_005390
• MIM: 602741
• UniProt ID: O43741