Recombinant Human PPME1 protein, GST-tagged

• Cat.No.: PPME1-195H
• Product Overview: Recombinant Human PPME1(2-end) fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: Protein phosphatase methylesterase 1 (PPME1) conducts the demethylation of the catalytic subunit of protein phosphatase 2A (PP2A) and leads to inactivation of the phosphatase. It is demonstrated that PPME1 binds directly to the active site of PP2A and evicts the manganese ions required for the phosphatase activity. PPME1 is also reported to protect ERK activity in human malignant glioma.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 70 kDa
• Protein length: 2-end
• Purity: >90%
• Applications: Methyltransferase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PPME1 protein phosphatase methylesterase 1 [ Homo sapiens ]
• Official Symbol: PPME1
• Synonyms: PPME1; protein phosphatase methylesterase 1; PME 1; protein phosphatase methylesterase-1; PME-1; FLJ22226
• Gene ID: 51400
• mRNA Refseq: NM_016147
• Protein Refseq: NP_057231
• MIM: 611117
• UniProt ID: Q9Y570
• Chromosome Location: 11q13.4
• Function: carboxylesterase activity; hydrolase activity; protein C-terminal methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity