Recombinant Human PPARD, His-tagged

• Cat.No.: PPARD-30676TH
• Product Overview: Recombinant fragment, corresponding to amino acids 165-441 of Human PPAR delta with His tag, approximately 32kDa.

Specification

• Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.
• Protein length: 165-441 a.a.

Gene Information

• Gene Name: PPARD peroxisome proliferator-activated receptor delta [ Homo sapiens ]
• Official Symbol: PPARD
• Synonyms: PPARD; peroxisome proliferator-activated receptor delta; peroxisome proliferative activated receptor, delta; FAAR; NR1C2; NUC1; NUCII
• Gene ID: 5467
• mRNA Refseq: NM_001171818
• Protein Refseq: NP_001165289
• MIM: 600409
• Uniprot ID: Q03181
• Chromosome Location: 6p21.2
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem
• Function: DNA binding; drug binding; fatty acid binding; ligand-dependent nuclear receptor activity; linoleic acid binding