Recombinant Human PON1, His-tagged

• Cat.No.: PON1-27936TH
• Product Overview: Recombinant full length PON1 protein (Human) with an amino-terminal hexahistidine tag.

Specification

• Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the paraoxonase family.

Gene Information

• Gene Name: PON1 paraoxonase 1 [ Homo sapiens ]
• Official Symbol: PON1
• Synonyms: PON1; paraoxonase 1; PON; serum paraoxonase/arylesterase 1; ESA; esterase A
• Gene ID: 5444
• mRNA Refseq: NM_000446
• Protein Refseq: NP_000437
• Uniprot ID: P27169
• Chromosome Location: 7q21.3
• Pathway: Metabolic pathways, organism-specific biosystem
• Function: aryldialkylphosphatase activity; arylesterase activity; arylesterase activity; calcium ion binding; hydrolase activity