Recombinant Human POGLUT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: POGLUT1-3323H
• Product Overview: KTELC1 MS Standard C13 and N15-labeled recombinant protein (NP_064616) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants.
• Molecular Mass: 46 kDa
• AA Sequence: MEWWASSPLRLWLLLFLLPSAQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTELTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: POGLUT1 protein O-glucosyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: POGLUT1
• Synonyms: POGLUT1; protein O-glucosyltransferase 1; C3orf9, chromosome 3 open reading frame 9, KTEL (Lys Tyr Glu Leu) containing 1, KTELC1; 9630046K23Rik; hCLP46; KDELC family like 1; KDELCL1; MDS010; MDSRP; MGC32995; Rumi; x 010 protein; CAP10-like 46 kDa protein; CAP10-like protein, 46 kDa; KTEL motif-containing protein 1; KTEL (Lys-Tyr-Glu-Leu) containing 1; myelodysplastic syndromes relative protein; CLP46; C3orf9; KTELC1
• Gene ID: 56983
• mRNA Refseq: NM_020231
• Protein Refseq: NP_064616
• MIM: 615618
• UniProt ID: Q8NBL1