Recombinant Human PLS3

• Cat.No.: PLS3-30836TH
• Product Overview: Recombinant full length Human T Plastin with a N terminal proprietary tag; Predicted MWt 95.3 kDa including the tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 630 amino acids
• Description: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.
• Molecular Weight: 95.300kDa inclusive of tags
• Tissue specificity: Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHEL FKEANMPLPGYKVREIIQKLMLDGDRNKDGKISFDEFVYI FQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHS YSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAV GDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLA LNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLF ADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFH LENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPR IDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVS GNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREE RTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPV DWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVG IGGQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKAN DDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLID AIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARV YALPEDLVEVKPKMVMTVFACLMGRGMKRV
• Sequence Similarities: Contains 2 actin-binding domains.Contains 4 CH (calponin-homology) domains.Contains 2 EF-hand domains.

Gene Information

• Gene Name: PLS3 plastin 3 [ Homo sapiens ]
• Official Symbol: PLS3
• Synonyms: PLS3; plastin 3; plastin 3 (T isoform); plastin-3; T plastin
• Gene ID: 5358
• mRNA Refseq: NM_001136025
• Protein Refseq: NP_001129497
• MIM: 300131
• Uniprot ID: P13797
• Chromosome Location: Xq23
• Function: actin binding; calcium ion binding