Recombinant Human plexin B2 Protein, His tagged

• Cat.No.: PLXNB2-025H
• Product Overview: Recombinant human Plexin B2 protein (O15031) (Leu 20-Pro 1197) with a His tag at the C-terminus was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 20-1197aa
• Description: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.
• Tag: C-His
• Molecular Mass: 130.8 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: PLXNB2 plexin B2 [ Homo sapiens (human) ]
• Official Symbol: PLXNB2
• Synonyms: PLXNB2; plexin B2; plexin-B2; KIAA0315; MM1; PLEXB2; Nbla00445; dJ402G11.3
• Gene ID: 23654
• mRNA Refseq: NM_012401
• Protein Refseq: NP_036533
• MIM: 604293
• UniProt ID: O15031