Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged

• Cat.No.: PDGFRB-1890H
• Product Overview: Recombinant humanPDGFRB catalytic domain (amino acids 558-1106), His-tagged was expressed ininsect cells. Its molecular weight is 66300 Dalton.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 558-1106 a.a.
• Description: PDGFRB is a receptortyrosine kinase and has been implicated in atherogenesis and in celltransformation by the SIS oncogene. No special measures were taken toactivate this kinase. PDGFRB encodes a cell surface tyrosine kinase receptorfor members of the platelet-derived growth factor family. These growthfactors are mitogens for cells of mesenchymal origin. The identity of thegrowth factor bound to a receptor monomer determines whether the functionalreceptor is a homodimer or a heterodimer, composed of both platelet-derivedgrowth factor receptor alpha and beta polypeptides. PDGFRB is flanked onchromosome 5 by the genes for granulocyte-macrophage colony-stimulatingfactor and macrophage-colony stimulating factor receptor; all three genes maybe implicated in the 5-q syndrome.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 66.3 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PDGFRB

Gene Information

• Gene Name: PDGFRB platelet-derived growth factorreceptor, beta polypeptide [ Homo sapiens ]
• Synonyms: PDGFRB;platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR;CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta;CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140bantigen; soluble PDGFRb variant; Beta-type platelet-derived growth factorreceptor
• Gene ID: 5159
• mRNA Refseq: NM_002609
• Protein Refseq: NP_002600
• MIM: 173410
• UniProt ID: P09619
• Chromosome Location: 5q33.1
• Pathway: Calcium signalingpathway; Cytokine-cytokine receptor interaction; Downstream signaltransduction; Focal adhesion; Gap junction; Glioma; HTLV-I infection; MAPKsignaling pathway; Melanoma; Pathways in cancer; PDGFR-alpha signalingpathway; Regulation of actin cytoskeleton; Signaling by PDGF; S1P1 pathway;S1P3 pathway
• Function: ATP binding; growthfactor binding; nucleotide binding; platelet activating factor receptoractivity; platelet-derivedgrowth factor alpha-receptor activity; platelet-derived growth factorbinding; platelet-derived growth factor receptor binding; proteinhomodimerization activity; platelet-derived growth factor-activated receptoractivity; protein binding; protein tyrosine kinase activity; receptoractivity; receptor bingding; signal transducer activity; vascular endothelialgrowth factor-activated receptor activity