Recombinant Human PLA2G4A

• Cat.No.: PLA2G4A-30736TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-110 of Human Phospholipase A2 with proprietary tag; Predicted MWt 37.73 kDa.

Specification

• Description: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
• Protein length: 110 amino acids
• Molecular Weight: 37.730kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVS
• Sequence Similarities: Contains 1 C2 domain.Contains 1 PLA2c domain.
• Tag: Non

Gene Information

• Gene Name: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) [ Homo sapiens ]
• Official Symbol: PLA2G4A
• Synonyms: PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha
• Gene ID: 5321
• mRNA Refseq: NM_024420
• Protein Refseq: NP_077734
• Uniprot ID: P47712
• Chromosome Location: 1q25
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ca-dependent events, organism-specific biosystem; Endothelins, organism-specific biosystem
• Function: calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; hydrolase activity; lysophospholipase activity