Recombinant Human PKMYT1 Protein (L2-T499), His/GST tagged

• Cat.No.: PKMYT1-0058H
• Product Overview: Recombinant Human 8His-GST-TEV-GG-PKMYT1(L2-T499 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Protein Length: L2-T499
• Description: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [ Homo sapiens (human) ]
• Official Symbol: PKMYT1
• Synonyms: PKMYT1; protein kinase, membrane associated tyrosine/threonine 1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; MYT1; myt1 kinase; FLJ20093; DKFZp547K1610
• Gene ID: 9088
• mRNA Refseq: NM_004203
• Protein Refseq: NP_004194
• MIM: 602474
• UniProt ID: Q99640