Recombinant Human Pim-2 Oncogene, GST-tagged, Active

• Cat.No.: PIM2-393H
• Product Overview: Recombinant human full-length PIM2 was expressed by baculovirus inSf9 cells usingan N-terminal GST tag. MW=61 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PIM2 pim-2 oncogene [ Homo sapiens ]
• Synonyms: PIM2; pim-2 oncogene; PIM; Proto-oncogene serine/threonine-protein kinase Pim-2; EC 2.7.11.1; Pim-2h
• Gene ID: 11040
• mRNA Refseq: NM_006875
• Protein Refseq: NP_006866
• UniProt ID: Q9P1W9
• Chromosome Location: Xp11.23
• MIM: 300295
• Pathway: Acute myeloid leukemia
• Function: ATP binding; nucleotide binding; transferase activity; protein serine/threonine kinase activity; metal ion binding