Recombinant Human PIK3CA protein, Flag-tagged, Biotinylated

• Cat.No.: PIK3CA-70H
• Product Overview: Recombinant Human PIK3CA[1-1068(end) amino acids of accession number NP_006209.2] was coexpressed as N-terminal DYKDDDDK tagged, biotinylated protein (128 kDa) with PIK3R1[1-724(end) amino acids of accession number NP_852664.1] in insect cell and biotinyl

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 1-1068;1-724 a.a.
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Molecular Mass: 128 kDa
• Purity: >90% as determined by SDS-PAGE and CBB staining
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide [ Homo sapiens ]
• Official Symbol: PIK3CA
• Synonyms: PIK3CA; PI3K; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA; p110-alpha; MGC142161; MGC142163
• Gene ID: 5290
• mRNA Refseq: NM_006218
• Protein Refseq: NP_006209
• MIM: 171834
• UniProt ID: P42336
• Chromosome Location: 3q26.3
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; insulin receptor substrate binding; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferase activity, alcohol group as acceptor; protein binding; protein kinase activator activity; protein serine/threonine kinase activity