Recombinant Human PEX, His-tagged

• Cat.No.: MMP2-14H
• Product Overview: Recombinant Human PEX produced inE. colihas a molecular mass of approximately 23 KDa.

Specification

• Cat. No.: MMP2-14H
• Description: PEX is the C-terminal hemopexin domain of Matrix Metalloproteinase-2. It has the activity of anti-angiogenesis, and a naturally occurring form of PEX can be detected in vivo. PEX can block angiogenesis and tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis.
• Purity: >95% as determined by SDS-PAGE.
• Specific Activity: Measured by its ability of suppressing angiogenesisin vitro.
• Formulation: The protein (1mg/ml) was lyophilized with 2mM Tris pH-7.4.
• Storage Buffer: Liquid. In PBS Buffer.
• Storagee: Lyophilized rHuPEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuPEX should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: MMP2
• Synonyms: CLG4; MONA; CLG4A; TBE-1; MMP-II; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); MMP2_HUMAN; 72 kDa type IV collagenase [Precursor]; EC 3.4.24.24.; 72 kDa gelatinase; 72kD type IV collagenase; Gelatinase A; Matrix metalloproteinase-2; collagenase type IV-A; matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD typeIV collagenase); matrix metalloproteinase-II; neutrophil gelatinase; MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
• Gene ID: 4313
• mRNA Refseq: NM_001127891
• Protein Refseq: NP_001121363
• MIM: 120360
• UniProt ID: P08253
• Chromosome Location: 16q13-q21
• Pathway: GnRH signaling pathway; Leukocyte transendothelial migration.
• Function: calcium ion binding;catalytic activity;metal ion binding;metalloendopeptidase activity;protein binding;zinc ion binding