Recombinant Human peptidylprolyl isomerase D Protein, His tagged

• Cat.No.: PPID-101H
• Product Overview: Recombinant human PPID protein (Q08752) (Gly 197-Ala 370) with a His tag at the C-terminus was expressed in E. coli.

Specification

• Description: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.
• Source: E. coli
• Species: Human
• Tag: C-His
• Protein length: 197-370aa
• Molecular Mass: 21.1 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: PPID peptidylprolyl isomerase D [ Homo sapiens (human) ]
• Official Symbol: PPID
• Synonyms: PPID; peptidylprolyl isomerase D; peptidylprolyl isomerase D (cyclophilin D); peptidyl-prolyl cis-trans isomerase D; cyclophilin 40; CYP 40; PPIase D; rotamase D; cyclophilin D; cyclophilin-40; cyclophilin-related protein; 40 kDa peptidyl-prolyl cis-trans isomerase D; CYPD; CYP-40; MGC33096
• Gene ID: 5481
• mRNA Refseq: NM_005038
• Protein Refseq: NP_005029
• MIM: 601753
• UniProt ID: Q08752