Recombinant Human PDK4, His-tagged

Cat. No. :	PDK4-653H
Description :	PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
Source :	Bacteria.
Storage :	Store at -80°C.

Gene Name	PDK4 pyruvate dehydrogenase kinase, isozyme 4 [ Homo sapiens ]
Synonyms	PDK4; pyruvate dehydrogenase kinase, isozyme 4; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; EC 2.7.11.2; FLJ40832
Gene ID	5166
mRNA Refseq	NM_002612
Protein Refseq	NP_002603
MIM	602527
UniProt ID	Q16654
Chromosome Location	7q21.3
Pathway	Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
Function	ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity