Recombinant Human PDK2, His-tagged

• Cat.No.: PDK2-29162TH
• Product Overview: RecombinantHuman PDK2 amino acids 16 - 407 with N-terminal His tag.

Specification

• Description: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Protein length: 392 amino acids
• Conjugation: HIS
• Tissue specificity: Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.
• Form: Liquid
• Storage buffer: pH: 7.50Constituents:0.08% DTT, 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.015% EDTA, 0.05% Triton-X-100
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the PDK/BCKDK protein kinase family.Contains 1 histidine kinase domain.

Gene Information

• Gene Name: PDK2 pyruvate dehydrogenase kinase, isozyme 2 [ Homo sapiens ]
• Official Symbol: PDK2
• Synonyms: PDK2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase kinase, isoenzyme 2; PDHK2
• Gene ID: 5164
• mRNA Refseq: NM_001199898
• Protein Refseq: NP_001186827
• MIM: 602525
• Uniprot ID: Q15119
• Chromosome Location: 17q21.33
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem; Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity