Recombinant Human PDIA3, His-tagged

• Cat.No.: PDIA3-120H
• Product Overview: The protein was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 161-505aa
• Description: This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: PDIA3 protein disulfide isomerase family A, member 3 [ Homo sapiens(human) ]
• Official Symbol: PDIA3
• Synonyms: PDIA3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; protein disulfide isomerase family A, member 3; protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; EC 5.3.4.1
• Gene ID: 2923
• mRNA Refseq: NM_005313
• Protein Refseq: NP_005304
• MIM: 602046
• UniProt ID: P30101
• Chromosome Location: 15q15
• Pathway: Adaptive Immune System; Antigen processing and presentation; Calnexin/calreticulin cycle
• Function: cysteine-type endopeptidase activity; electron carrier activity; protein binding