Recombinant Human Paraoxonase 2, His-tagged

• Cat.No.: PON2-50H
• Product Overview: Recombinant Human Paraoxonase-2 is expressed inE. colihaving a molecular weight of 43.5 kDa and fused to an amino terminal hexahistidine tag. The PON2 purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Paraoxonase 2 (PON2) is a member of a multigene family whose genes share 65% identity at the amino acid level, and is expressed in a variety of tissues, including the pancreas. PON2 overexpression has been shown to lower the intracellular oxidative state and reduce the cells ability to oxidize LDL. PON2 is therefore implicated in the modulation of oxidative stress.
• Physical Appearance: Sterile Filtered clear solution.
• Purity: Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.
• Formulation: 0.1 mg/ml PON2 is supplied in PBS and 50% glycerol.
• Application: Arylesterase 2 can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
• Storage Conditions: Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: PON2 paraoxonase 2 [ Homo sapiens ]
• Synonyms: PON2; paraoxonase 2; paraoxonase nirs;Serum paraoxonase/arylesterase 2;EC=3.1.1.2;EC=3.1.8.1; Serum aryldialkylphosphatase 2; A-esterase 2; Aromatic esterase 2; EC 3.1.1.2; EC 3.1.8.1
• Gene ID: 5445
• mRNA Refseq: NM_000305
• Protein Refseq: NP_000296
• MIM: 602447
• UniProt ID: Q15165
• Chromosome Location: 7q21.3
• Pathway: gamma-Hexachlorocyclohexane degradation; Bisphenol A degradation; Metabolic pathways
• Function: aryldialkylphosphatase activity; arylesterase activity; hydrolase activity; identical protein binding