Recombinant Human Nuclear Factor Of Activated T-cells, Cytoplasmic, Calcineurin-Dependent 1, His-tagged

• Cat.No.: NFATC1-1274H
• Product Overview: Recombinant humanNFATC1 contains amino acids 2-298 and N-terminal polyhistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-298 a.a.
• Description: NFATC1 is a member of the NFATfamily of proteins which are Ca2+/calcineurin-responsivetranscription factors primarily recognized for their central roles in Tlymphocyte activation and cardiac valve development. NFAT consists of atleast two components: a preexisting cytosolic component that translocates tothe nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclearcomponent.
• Form: Carrier-free liquid.
• Molecular Weight: 35 kDa(migrates at ~ 48 kDa on SDS-PAGE gel)
• Purity: 95% asdetermined by SDS-PAGE analysis
• Biological Activity: Recombinanthuman NFATC1 is phosphorylatable in vitro,using recombinant GSK3 and PKA. Optimization of the cell stimulationprotocol, cell lysis procedure, and reaction conditions may be required foreach specific application.
• storage: Store at2-4°C for short term storage. Stable for 1 year in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: NFATC1
• Pathways: Axon guidance; B cell receptorsignaling pathway; Natural killer cell mediated cytotoxicity; T cell receptorsignaling pathway; VEGF signaling pathway; Wnt signaling pathway

Gene Information

• Gene Name: NFATC1 nuclear factor ofactivated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens]
• Synonyms: NFATC1; nuclear factor ofactivated T-cells, cytoplasmic, calcineurin-dependent 1; NFAT2; NFATc; NF-ATC;MGC138448; NFAT transcription complex cytosolic component; Nuclear factor ofactivated T-cells, cytoplasmic 1; NF-ATc1; NFATC; NFAT transcription complexcytosolic component
• Gene ID: 4772
• mRNA Refseq: NM_006162
• Protein Refseq: NP_006153
• MIM: 600489
• UniProt ID: O95644
• Chromosome Location: 18q23
• Function: FK506 binding; promoter binding;protein binding; transcription activator activity; transcription factoractivity