Recombinant Human NOSTRIN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: NOSTRIN-548H
• Product Overview: NOSTRIN MS Standard C13 and N15-labeled recombinant protein (NP_001034813) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Myc&DDK
• Description: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.
• Molecular Mass: 57.7 kDa
• AA Sequence: MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKATRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: NOSTRIN nitric oxide synthase trafficker [ Homo sapiens (human) ]
• Official Symbol: NOSTRIN
• Synonyms: NOSTRIN; nitric oxide synthase trafficker; nostrin; MGC20702; BM247 homolog; ENOS traffic inducer; eNOS-trafficking inducer; nitric oxide synthase trafficking; nitric oxide synthase traffic inducer; endothelial nitric oxide synthase traffic inducer; ortholog of mouse disabled 2 interacting proein 2; DaIP2
• Gene ID: 115677
• mRNA Refseq: NM_001039724
• Protein Refseq: NP_001034813
• MIM: 607496
• UniProt ID: Q8IVI9