Recombinant Human NFKBIA, GST-tagged

• Cat.No.: NFKBIA-1463H
• Product Overview: Recombinant full-length human IkappaBalpha was expressed inE. colicells using an N-terminal GST tag. MW = 61kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: IκBα is an inhibitor of the NFκB complex and inactivates the NFκB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IκB protein by IκB kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFκB complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the IκB protein thereby inhibiting the activity of the NFκB complex. Overexpression of the IκBα gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [ Homo sapiens ]
• Synonyms: NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IKBA; MAD-3; NFKBI; IkappaBalpha; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; Major histocompatibility complex enhancer-binding protein MAD3; nuclear factor of kappa light chain gene enhancer in B-cells
• Gene ID: 4792
• mRNA Refseq: NM_020529
• Protein Refseq: NP_065390
• MIM: 164008
• UniProt ID: P25963
• Chromosome Location: 14q13
• Pathway: Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chemokine signaling pathway; Chronic myeloid leukemia; Epithelial cell signaling in Helicobacter pylori infection; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system; Signalling by NGF
• Function: NF-kappaB binding; NF-kappaB binding; heat shock protein binding; identical protein binding; nuclear localization sequence binding; protein complex binding; ubiquitin protein ligase binding