Recombinant Human NFKB1(Met1-Gly434) Protein, N-6*His-tagged

• Cat.No.: NFKB1-106H
• Product Overview: Recombinant Human NFKB1(P19838-2)(Met1-Gly434) Protein, fused with a 6*His tag at the N-terminus, was produced in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20mM GSH, pH 8.0.
• Molecular Mass: The recombinant Human NFKB1 Protein has a predicted molecular mass of 49.7kDa, it migrates with an apparent molecular mass of 45-55kDa under reducing conditions.
• AA Sequence: Met1-Gly434
• Endotoxin: < 0.01 EU per μg of the protein as determined by the LAL method.
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Protein length: Met1-Gly434

Gene Information

• Gene Name: NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [ Homo sapiens ]
• Official Symbol: NFKB1
• Synonyms: NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor NF-kappa-B p105 subunit; KBF1; NF kappaB; NF kB1; NFkappaB; NFKB p50; p50; p105; NF-kappabeta; DNA binding factor KBF1; DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; EBP-1; NF-kB1; NFKB-p50; NF-kappaB; NFKB-p105; NF-kappa-B; MGC54151; DKFZp686C01211
• Gene ID: 4790
• mRNA Refseq: NM_001165412
• Protein Refseq: NP_001158884
• MIM: 164011
• UniProt ID: P19838

Reviews

06/16/2022

Potent biological activity of NFKB1, combined with its high purity, provides accurate and reliable experimental data for the research field.

04/22/2022

The short half-life and high clearance of NFKB1 allow its rapid action and rapid clearance in vivo, improving therapeutic efficiency.

05/21/2019

Beacuse production process of NFKB1 realizes the minimization of waste and the minimal impact on the environment, which is truly green production.

Q&As

What is the role of NFKB1 protein in autoimmune diseases?

NFKB1 protein is involved in the occurrence and progression of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

What is the relationship between NFKB1 protein and apoptosis?

NFKB1 protein plays a complex role in apoptosis and may promote or inhibit the occurrence of apoptosis.

What drugs interact with the NFKB1 protein?

A variety of drugs have been developed that target the NFKB1 protein and its downstream signaling pathways, such as inhibiting NFKB1 activation or inhibiting the transcriptional activity of NFKB1 downstream genes.

Does the NFKB1 protein study have implications for new drug development?

The protein plays a key role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of NFKB1 protein will help the development of new drugs, such as targeted drugs targeting NFKB1 protein and its signaling pathway may be applied to the treatment of related diseases.

Is there a potential application of NFKB1 protein in the design of immune vaccines?

This protein plays an important role in the activation of immune cells and the regulation of inflammation, so it can be used in immune vaccine design to enhance immune effects.

Why does NFKB1 protein have a pattern of expression in immune cells?

The expression pattern of NFKB1 protein in immune cells is regulated by different stimuli and environments, and participates in the activation and regulation of immune cells.