Recombinant Human NDP, His-tagged

• Cat.No.: NDP-2290H
• Product Overview: Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 132aa
• Description: Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 14.8 kDa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRSSCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
• Purity: >80% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: NDP Norrie disease (pseudoglioma) [ Homo sapiens ]
• Official Symbol: NDP
• Synonyms: NDP; Norrie disease (pseudoglioma); EVR2, exudative vitreoretinopathy 2 (X linked); norrin; norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; ND; EVR2; FEVR
• Gene ID: 4693
• mRNA Refseq: NM_000266
• Protein Refseq: NP_000257
• MIM: 300658
• UniProt ID: Q00604
• Chromosome Location: Xp11.4-p11.3
• Function: cell surface binding; cytokine activity; frizzled binding; growth factor activity; protein homodimerization activity