Recombinant Human NCSTN Protein, MYC/DDK-tagged

• Cat.No.: NCSTN-469H
• Product Overview: Recombinant human NCSTN protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProtKB/Swiss-Prot Function]
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 75.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: nicastrin [ Homo sapiens ]
• Official Symbol: NCSTN
• Synonyms: ATAG1874
• Gene ID: 23385
• mRNA Refseq: NM_015331.2
• Protein Refseq: NP_056146.1
• MIM: 605254
• UniProt ID: Q92542