Recombinant Human NAD(P)H Dehydrogenase, Quinone 2, His-tagged

• Cat.No.: NQO2-2055H
• Product Overview: Recombinant human NQO2 protein fused to His-tag was expressed inE.coliand purified by using conventional chromatography techniques. 28.1 kDa (251aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: NQO2 is a member of the NAD(P)H dehydrogenase (quinone). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NQO2 NAD(P)H dehydrogenase, quinone 2 [ Homo sapiens ]
• Synonyms: NAD(P)H dehydrogenase, quinone 2; QR2; DHQV; DIA6; NMOR2; NQO2; ribosyldihydronicotinamide dehydrogenase; quinone reductase 2; NRH:quinone oxidoreductase 2; NRH dehydrogenase [quinone] 2; NAD(P)H menadione oxidoreductase 2, dioxin-inducible; NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2; OTTHUMP00000015953; OTTHUMP00000015949; Quinone reductase 2; EC 1.10.99.2
• Gene ID: 4835
• mRNA Refseq: NM_000904
• Protein Refseq: NP_000895
• MIM: 160998
• UniProt ID: P16083
• Chromosome Location: 6pter-q12
• Function: NADPH dehydrogenase (quinone) activity; coenzyme binding; dihydronicotinamide riboside quinone reductase activity; electron carrier activity; metal ion binding