Recombinant Human MYSM1 Protein (A2-M828), His tagged

• Cat.No.: MYSM1-0684H
• Product Overview: Recombinant Human 6His-TEV-GG-MYSM1(A2-M828 end) Protein was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: A2-M828
• Description: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: MYSM1 Myb-like, SWIRM and MPN domains 1 [ Homo sapiens (human) ]
• Official Symbol: MYSM1
• Synonyms: MYSM1; Myb-like, SWIRM and MPN domains 1; histone H2A deubiquitinase MYSM1; KIAA1915; myb-like, SWIRM and MPN domain-containing protein 1; 2ADUB; 2A-DUB; RP4-592A1.1; DKFZp779J1554; DKFZp779J1721
• Gene ID: 114803
• mRNA Refseq: NM_001085487
• Protein Refseq: NP_001078956
• MIM: 612176
• UniProt ID: Q5VVJ2