Recombinant Human MNDA, His-tagged

• Cat.No.: MNDA-30037TH
• Product Overview: Recombinant full length Human MNDA with N-terminal His Tag; 427aa, 47.9kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 407 amino acids
• Description: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.
• Conjugation: HIS
• Molecular Weight: 47.900kDa inclusive of tags
• Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.02% DTT, 0.32% Tris HCl
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN
• Sequence Similarities: Contains 1 DAPIN domain.Contains 1 HIN-200 domain.

Gene Information

• Gene Name: MNDA myeloid cell nuclear differentiation antigen [ Homo sapiens ]
• Official Symbol: MNDA
• Synonyms: MNDA; myeloid cell nuclear differentiation antigen; PYHIN3
• Gene ID: 4332
• mRNA Refseq: NM_002432
• Protein Refseq: NP_002423
• MIM: 159553
• Uniprot ID: P41218
• Chromosome Location: 1q22
• Function: DNA binding