Recombinant Human MMP2 protein, His-tagged
Cat.No. : | MMP2-890H |
Product Overview : | Recombinant Human MMP2 protein (Ala30-Cys660), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
Protein Length : | 631 |
Description : | Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2/CLG4A contains 3 fibronectin type-II domains and 4 hemopexin-like domains. MMP-2 is produced by normal skin fibroblasts. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. MMP2 involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 71.8 kDa. The predicted N-terminus is Ala 30. The reducing (R) protein migrates as 66-71 kDa in SDS-PAGE . |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >92% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name | MMP2 |
Official Symbol | MMP2 |
Synonyms | MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4, CLG4A, matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) , matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); 72 kDa type IV collagenase; TBE 1; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II; CLG4; MONA; CLG4A; TBE-1; MMP-II |
Gene ID | 4313 |
mRNA Refseq | NM_001127891 |
Protein Refseq | NP_001121363 |
MIM | 120360 |
UniProt ID | P08253 |
◆ Recombinant Proteins | ||
MMP2-5990C | Recombinant Chicken MMP2 | +Inquiry |
Mmp2-1019M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
MMP2-8392HP | Recombinant Human MMP2 protein, GST-tagged, R-PE labeled | +Inquiry |
MMP2-450H | Recombinant Human matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), His-tagged | +Inquiry |
Mmp2-1785M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
◆ Native Proteins | ||
MMP2-8455M | Native Mouse MMP2 | +Inquiry |
MMP2-46H | Native Human MMP-2 | +Inquiry |
MMP2-29475TH | Native Human MMP2 | +Inquiry |
MMP2-47H | Native Human MMP-2/TIMP-2 Complex | +Inquiry |
◆ Cell & Tissue Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
Not For Human Consumption!
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