Recombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), His-tagged

• Cat.No.: MET-1272H
• Product Overview: Recombinant humanMET catalytic domain (amino acids 956-1390) with N-terminal His tag.

Specification

• Cat. No.: MET-1272H
• Description: MET is a receptor-liketyrosine kinase whose disregulation has been linked to many types of humanmalignancies. No special measures were taken to activate this kinase.
• Source: insect cells
• Species: Human
• Form: Liquid in 20 mMTris, pH 7.5 + 100 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol
• Molecular Weight: 53.7 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MET
• Protein length: 956-1390 a.a.

Gene Information

• Gene Name: MET met proto-oncogene(hepatocyte growth factor receptor) [ Homo sapiens ]
• Synonyms: MET; metproto-oncogene (hepatocyte growth factor receptor); HGFR; AUTS9; RCCP2;c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; oncogeneMET; HGF/SF receptor; OTTHUMP00000024917; OTTHUMP00000069168; proto-oncogenec-Met; scatter factor receptor; tyrosine-protein kinase Met; metproto-oncogene tyrosine kinase; EC 2.7.10.1; EC 2.7.10
• Gene ID: 4233
• mRNA Refseq: NM_000245
• Protein Refseq: NP_000236
• MIM: 164860
• UniProt ID: P08581
• Chromosome Location: 7q31
• Pathway: Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Bacterial invasion of epithelialcells; Cytokine-cytokine receptor interaction; Developmental Biology;Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; FGFsignaling pathway; Melanoma; Pathways in cancer; Renal cell carcinoma;Semaphorin interactions; Signaling events mediated by TCPTP;Syndecan-1-mediated signaling events
• Function: ATP binding;hepatocyte growth factor-activated receptor activity; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity