Recombinant Human MEK6, GST-tagged

• Cat.No.: MAP2K6-47H
• Product Overview: Recombinant full-length human MEK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: MEK6 or MAP2K6(mitogen-activated protein kinase kinase 6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase that also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MEK6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~64 kDa
• Applications: Kinase Assay, Western Blot
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens ]
• Official Symbol: MAP2K6
• Synonyms: MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK kinase 6; stress-activated protein kinase kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK-3
• Gene ID: 5608
• mRNA Refseq: NM_002758
• Protein Refseq: NP_002749
• MIM: 601254
• UniProt ID: P52564
• Chromosome Location: 17q
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDC42 signaling events, organism-specific biosystem; CDO in myogenesis, organism-specific biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase activity; nucleotide binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity