Recombinant Human MBNL1, MYC/DDK-tagged

• Cat.No.: MBNL1-2742H
• Product Overview: Recombinant full-length Human MBNL1, transcript variant 3, fused with C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Myc&DDK
• Description: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It has been implicated in Myotonic dystrophy and has been shown to autoregulate its transcript. Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 41.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: MBNL1 muscleblind-like splicing regulator 1 [ Homo sapiens ]
• Official Symbol: MBNL1
• Synonyms: EXP; MBNL; EXP35; EXP40; EXP42; muscleblind-like protein 1; triplet-expansion RNA-binding protein
• Gene ID: 4154
• mRNA Refseq: NM_207293
• Protein Refseq: NP_997176
• MIM: 606516
• UniProt ID: Q9NR56
• Chromosome Location: 3q25
• Pathway: Adipogenesis, organism-specific biosystem
• Function: RNA binding; double-stranded RNA binding; metal ion binding