Recombinant Human LRP5

• Cat.No.: LRP5-29428TH
• Product Overview: Recombinant fragment corresponding to amino acids 41-130 of Human LRP5 protein with an N terminal proprietary tag; 35.53 kDa inclusive of tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 90 amino acids
• Description: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
• Molecular Weight: 35.530kDa inclusive of tags
• Tissue specificity: Widely expressed, with the highest level of expression in the liver.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.03% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: RDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETN
• Sequence Similarities: Belongs to the LDLR family.Contains 4 EGF-like domains.Contains 3 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats.

Gene Information

• Gene Name: LRP5 low density lipoprotein receptor-related protein 5 [ Homo sapiens ]
• Official Symbol: LRP5
• Synonyms: LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1 , LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS
• Gene ID: 4041
• mRNA Refseq: NM_002335
• Protein Refseq: NP_002326
• MIM: 603506
• Uniprot ID: O75197
• Chromosome Location: 11q13.4
• Pathway: MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling network, organism-specific biosystem
• Function: Wnt-activated receptor activity; Wnt-protein binding; coreceptor activity; protein binding; receptor activity