Recombinant Human LIN7C Protein, MYC/DDK-tagged

• Cat.No.: LIN7C-641H
• Product Overview: Recombinant human LIN7C protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [UniProtKB/Swiss-Prot Function]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 21.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: lin-7 homolog C, crumbs cell polarity complex component[ Homo sapiens ]
• Official Symbol: LIN7C
• Synonyms: LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3
• Gene ID: 55327
• mRNA Refseq: NM_018362.3
• Protein Refseq: NP_060832.1
• MIM: 612332
• UniProt ID: Q9NUP9