Recombinant Human LILRB1, His-tagged

• Cat.No.: LILRB1-7871H
• Product Overview: Recombinant Human Leukocyte ImmunoglobulinLike Receptor Subfamily B Member 1/LILRB1 produced by transfected human cell is a secreted protein with sequence (Gly24His458) of Human LILRB1 fused with a polyhistidine tag at the Cterminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: The immunoglobulinlike transcript (ILT) family (also named leukocyte Iglike receptors (LIR) and monocyte/macrophage Iglike receptors (MIR)) can be activating and inhibitory immunoreceptors. ILTs are expressed on many leukocyte subsets and regulators of immune responses . ILTs share significant homology with killer cell Iglike receptors (KIR). Except ILT6, all ILT family members are type I transmembrane proteins having two or four extracellular Iglike domains . ILT2 is expressed on most monocytes,dendritic cells,and mature B cells. ILT2 is also expressed on small percentages of Tcells and NK cells. ILT2 can prevents cellular activation.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
• AA Sequence: GHLPKPTLWA EPGSVITQGS PVTLRCQGGQ ETQEYRLYRE KKTAPWITRI PQELVKKGQF PIPSITWEH AGRYRCYYGS DTAGRSESSD PLELVVTGAY IKPTLSAQPS PVVNSGGNVT L QCDSQVAF DGFILCKEGE DEHPQCLNSQ PHARGSSRAI FSVGPVSPSR RWWYRCYAYD SN SPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE TLTLQCGSDA GYNRFVLYKD GER DFLQLA GAQPQAGLSQ
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 [ Homo sapiens ]
• Official Symbol: LILRB1
• Synonyms: LILRB1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85; CD85j; ILT2; LIR 1; LIR1; MIR 7; ILT-2; CD85 antigen; Ig-like transcript 2; leukocyte Ig-like receptor-1; immunoglobulin-like transcript 2; CD85 antigen-like family member J; leukocyte immunoglobulin-like receptor 1; monocyte/macrophage immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; MIR7; CD85J; LIR-1; MIR-7; FLJ37515
• Gene ID: 10859
• mRNA Refseq: NM_001081637
• Protein Refseq: NP_001075106
• MIM: 604811
• UniProt ID: Q8NHL6
• Chromosome Location: 19q13.4
• Pathway: Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem
• Function: HLA-A specific inhibitory MHC class I receptor activity; HLA-B specific inhibitory MHC class I receptor activity; MHC class I protein binding; MHC class I protein binding; MHC class I protein binding; MHC class I receptor activity; SH2 domain binding; protein homodimerization activity; protein phosphatase 1 binding; receptor activity